EUROPEAN ASSOCIATION FOR THE STUDY OF THE LIVER

Biliary Fibrosis: Pathophysiology and translational opportunities

 

May, 12-13 Florence
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  P05-01 Long-term treatment with fibrates and ursodeoxycholic acid in people with primary sclerosing cholangitis is safe and associated with persistent clinical and biochemical improvement Matteo Peviani Received Received
  P01-01 Acute hepatocytic loss of endosomal sorting complex Retromer increases proliferation of biliary epithelial cells (BECs) Markus Barbosa Received Received
  P04-01 Chronic ketamine-induced sclerosing cholangitis associated with early inflammatory bowel disease after long term topical use Gerond Lake-Bakaar MD. PhD, Received Received
  P03-01 CRISPR-engineered chemically-derived hepatic progenitor cancer organoid recapitulates intrahepatic cholangiocarcinoma carcinogenesis and pathophysiology Michael Adisasmita Received Received
  P02-1 Liquid biopsy protein biomarkers of cholangiocarcinoma risk, early diagnosis and survival mirroring tumor cells Ainhoa Lapitz Received Received
  P02-02 Functional dichotomy of biliary primary cilia in liver injury and cholangiocarcinoma development Jinbiao Chen Received Received
  P03-02 Metabolic rewiring of cystic cholangiocytes improves mitochondrial dynamics and bioenergetics ameliorating the pathogenesis of polycystic liver disease in experimental models Enara Markaide Received Received
  P04-02 Mice lacking the NO receptor develop biliary fibrosis and become worsen upon feeding Western diet Muhammad Ashfaq Khan Received Received
  P01-02 An organotypic model of ductular reaction reveals a role of lipid biosynthesis in biliary cell activation Giovanni Sorrentino Received Received
  P05-2 scRNA transcriptomics analysis of cellular cross talk in fibrocystin-defective mice revelas a central role for cholangiocytes, neutrophils and double-negative T cells Zehra Syeda Received Received
  P04-03 Thy-1 expression in liver histology correlates with fibrosis grading in patients with primary biliary cholangitis Mirjam Kolev Received Received
  P05-03 Claudin-1 is a therapeutic target for primary sclerosing cholangitis Fabio Del Zompo Received Received
  P03-3 Large CD103 CD69 CD8 T cells consistently invade biliary epithelial cells in patients with primary biliary cholangitis Scott Davies Received Received
  P02-03 Hematopoietic-biliary organoids as a model for liver development and injury Susanna Quach Received Received
  P01-03 Quantitative MRCP differentiates between malignant and benign biliary obstructions Sarah Finnegan Received Received
  P03-04 Targeting OX40 signalling to modulate regulatory T cells and reduce biliary fibrosis Wei-Yu Lu Received Received
  P01-04 Characterizing and manipulating GPR35-dependent mast cell activity in PSC Georg Schneditz Received Received
  P04-04 Primary biliary cholangitis symptoms are reduced in Mcpip1fl/flAlbCre mice after pharmacological treatment Katarzyna Trzos Received Received
  P05-04 Dimethyl-fumarate attenuates cholestatic liver injury in mice Ester Dohnalkova Received Received
  P02-04 Identification of the role of osteopontin in biliary atresia Natalia Nieto Received Received
  P03-05 Combined inhibition of bile salt synthesis and intestinal bile salt uptake ameliorates cholestatic liver damage and reduces colonic bile salt levels in mice Stan van de Graaf Received Received
  P01-05 Necroptosis contributes to liver inflammation and fibrosis in experimental primary sclerosing cholangitis Pierre-Antoine Soret Received Received
  P02-05 Transcriptomic risk score predicts response to obeticholic acid and identifies genes linked with metabolic remodelling, autophagy, senescence and fibrosis in patients with PBC Hussain Syed Received Received
  P04-05 Mertk-expressing macrophages promote the malignant features of cholangiocarcinoma cells Mirella Pastore Received Received
  P01-06 Multimodal decoding of the mesenchymal landscape of human biliary fibrosis David Wilson Received Received
  P05-06 Recurrence of primary sclerosing cholangitis after liver transplantation: a single center data Elisa Catanzaro Received Received
  P02-06 CD8 T cells from patient with primary biliary cholangitis express e-cadherin upon T cell receptor activation and invade biliary epithelial cells through e-cadherin-beta-catenin interaction Vincenzo Ronca Received Received
  P04-06 Biliary atrasia human cholangiocyte organoids demonstrate increased oxidative stress response Yara Hamody Received Received
  P03-06 Beta-caryophyllene a CB2 specific agonist prevents the development of hepatopulmonary syndrome in experimental model of biliary cirrhosis Akash Mourya Received Received
  P04-07 Oval cells as new players of the inflammatory response during cholestatic liver damage: role of the EGFR pathway Aránzazu Sánchez Received Received
  P02-07 Mitochondrial dynamics and autophagy are disturbed in experimental models of primary biliary cholangitis, contributing to disease pathogenesis Irune Lasa Received Received
  P05-07 Hepatic recompensation upon treatment with ursodeoxycholic acid in PBC patients with decompensated cirrhosis Lukas Burghart Received Received
  P01-07 Silencing CNNM4 in cholangiocarcinoma inhibits tumoral progression by means of non-canonical ferroptosis Maria Mercado-Gómez Received Received
  P03-07 Patient proteomic data and mouse model reinforce the proinflammatory role of CCL24 in cholestatic disease Greenman Raanan Received Received
  P02-08 Identification of a functional relationship between MEK5-ERK5 pathway and hypoxia inducible factor 1-alfa Alessio Menconi Received Received
  P03-08 Non-invasive evaluation of progression to primary biliary cholangitis in patients with positive antimitochondrial antibodies MARTA ALONSO PEÑA Received Received
  P04-08 Radiomics features for risk stratification in primary sclerosing cholangitis: a proof-of-concept study Laura Cristoferi Received Received
  P01-08 Harnessing immune dysregulation in the search for serum biomarkers for diagnosis and prognosis of primary sclerosing cholangitis Lander Heyerick Received Received
  P05-08 Liver re-transplantation for recurrent primary sclerosing cholangitis: how far we can go? Chiara Mazzarelli Received Received
  P04-09 Bile duct injury in mdr2 knockout mice can be repaired with n-acetylcysteine treatment Adi Har-Zahav Received Received
  P02-09 Primary cilia as a targetable node between biliary injury, senescence and regeneration in liver transplantation Sofia Ferreira Gonzalez Received Received
  P01-09 Beta 7 integrin and L-in contribute to cholestatic liver disease in mice Agnes Seeger Received Received
  P05-09 Biliary senescence affects the transcriptomic landscape of murine hepatocytes Marisa F. Ferreira Received Received
  P03-09 Primary sclerosing cholangitis with features of autoimmune hepatitis: phenotypic characterization and prognosis Mirjam Kolev Received Received
  P05-10 Extracellular matrix remodeling in the progression of primary sclerosing cholangitis to cholangiocarcinoma: insights from an animal model Massimiliano Cadamuro Received Received
  P04-10 Increased protein tyrosine phosphatase non-receptor type 2 activity in primary sclerosing cholangitis Madita Determann Received Received
  P02-10 Neutrophils in the pathogenesis of primary sclerosing cholangitis Nidhi Jalan-Sakrikar Received Received
  P01-10 Dynamics of spleen stiffness measurement in patients with primary biliary cholangitis predict disease progression: a pilot study Micol Cittone Received Received
  P03-10 A3907, a systemic ASBT inhibitor, improves cholestasis and biliary fibrosis in mice by multi-organ activity and shows translational relevance to human Francisco J. Caballero Received Received
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Biliary Fibrosis: Pathophysiology and translational opportunities

 

May, 12-13 Florence
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