International Liver Congress™ 2022


22-26 June, 2022 London
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SAT-125 Fecal microbiota trasplant using endosco.. Ramon Bartolí .. .. Metabolism, alcohol and toxicity.. - -
SAT-126 Reversing diet-induced steatohepatitis a.. Rinat Abramovitch .. Adi S. Yehezkel Nathalie Abudi.. Metabolism, alcohol and toxicity.. - -
FRI-126 Mitochondria-derived methylmalonic acid .. Qi Huang .. .. Metabolism, alcohol and toxicity.. - -
SAT-127 Spontaneous and drug-induced histologica.. Grazia Pennisi .. .. Metabolism, alcohol and toxicity.. - -
SAT-128 Synergistic activity of GLP-1 peptide an.. Martijn Fenaux .. .. Metabolism, alcohol and toxicity.. - -
SAT-129 Preclinical pharmacology of low molecula.. Martijn Fenaux .. .. Metabolism, alcohol and toxicity.. - -
SAT-130 Integrated transcriptomics of CRV431 tre.. Patrick Mayo .. P. Mayo, S. Harrison, T Hobbs,.. Metabolism, alcohol and toxicity.. - -
SAT-131 Pharmacokinetic (PK) and pharmacodynamic.. Naim Alkhouri .. .. Metabolism, alcohol and toxicity.. - -
SAT-132 HEC96719, a novel tricyclic farnesoid X .. Yan Wang .. .. Metabolism, alcohol and toxicity.. - -
SAT-133 Effect of saroglitazar in reducing liver.. krishnadas devadas .. Avisek Chakravorty, Swetha Sat.. Metabolism, alcohol and toxicity.. - -
SAT-134 Intrahepatic microcirculation disorders .. Tatiana Ermolova .. .. Metabolism, alcohol and toxicity.. - -
SAT-135 Ticagrelor, but not clopidogrel, attenua.. Hyunwoo Oh .. .. Metabolism, alcohol and toxicity.. - -
SAT-136 Lemon balm extract ALS-L1023, an angioge.. Hyo Young Lee .. .. Metabolism, alcohol and toxicity.. - -
SAT-137 Hepatocyte-specific JNK signaling is pro.. Ines Volkert .. .. Metabolism, alcohol and toxicity.. - -
SAT-138 Semaglutide use in adjunct to multidisci.. Rochelle Wong .. Steven Mathews MD, Carolyn New.. Metabolism, alcohol and toxicity.. - -
SAT-139 Pegozafermin improved liver histology, l.. Rohit Loomba .. .. Metabolism, alcohol and toxicity.. - -
SAT-140 Identification of new therapeutic target.. Shainan Hora .. .. Metabolism, alcohol and toxicity.. - -
SAT-141 The effects of dietary vitamin E intake .. Carolin Victoria Schneider .. .. Metabolism, alcohol and toxicity.. - -
SAT-142 Favorable safety profile of TERN-201, a .. Mazen Noureddin .. Mazen Noureddin, Eric Lawitz, .. Metabolism, alcohol and toxicity.. - -
SAT-143 Pegozafermin led to significant metaboli.. Naim Alkhouri .. Rohit Loomba, Juan P Frias, Li.. Metabolism, alcohol and toxicity.. - -

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Thunderstorm-related asthma in patients sensitised to olea europaea pollen: twenty emergency department visits for asthmatic symptoms in one single day Losappio, Laura1; Heffler, Enrico2; Falco, Antonio1; Contento, Francesco1; Cannito, Cosimo1; Rolla, Giovanni2 1"Dimiccoli" Hospital, Emergency Department, Barletta, Italy; 2University of Torino - AO Mauriziano "Umberto I", Allergy and Clinical Immunology, Torino, Italy

Background: Associations between thunderstorm and asthma morbidity have been reported in several countries. Common to all epidemics of thunderstorm-related asthma is a significant increase in atmospheric allergen load during and immediately after a thunderstorm. Sensitization to Alternaria species or to grass and parietaria pollens has been suggested to play a key role in thunderstorm-related asthma. The only reported event of thunderstorm-related asthma in Mediterranean area was attributed to sensitization to parietaria pollen.

Method: here we describe a series of 20 patients who presented to Emergency Department in Barletta (94,000 inhabitants), Puglia (Italy) for sudden and severe asthmatic symptoms between May 27th and 28th 2010 (from15:36 to 5:02), immediately after a violent thunderstorm which occurred following a very hot morning (mean temperature: 29°C). All the patients have been subsequently visited by an allergist and underwent allergological work-up which included skin prick tests and a careful clinical history. Local pollen counts were available.

Result: Between May 10th and June 10th 2010, 86 Emergency Department asthma visits were recorded, 20 of them during the study day. Patients' mean age was 44.25 +/- 18.5 years (range: 9-81), 8/20 females, 2 smokers, 16 with a previous history of known respiratory allergy. Only two patients regularly took anti-asthma drugs. All 20 patients were sensitized to Olea europaea pollen, 7 of whom were monosensitized. Ten patients were sensitized to grass, 7 to parietaria, 5 to compositae, 5 to cypress, 5 to house dust mites, 3 to dog and 1 to cat danders. No patient was sensitized to Alternaria. Mean pollen count was 17 granules/m3 for Olea europaea, 6 granules/m3 for grass pollen.

Conclusion: This is, in our knowledge, the second epidemic of thunderstorm related asthma described in Mediterranean area and the first one in which sensitization to Olea europaea played a key-role. In conclusion, our report indicates that thunderstorm asthma may involve different allergens (not only fungal spores and grass or parietaria pollen) in different geographic areas, depending on the seasonality of thunderstorms and allergenic pollen.

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