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International Liver Cancer Association 15th Annual Conference

 

September 2 - 5, 2021 Virtual Conference
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Discussion forum - International Liver Cancer Association 15th Annual Conference
    Topic - 1. Molecular Pathogenesis, Cell Biology and Translational Research

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Poster: 11
Visits: 84
Title: The TUMOR SUPPRESOR ROLE OF THE a1-Na/K-ATPase/Src-p/PI3K SIGNALOSOME in NASH Related Hepatocellular Carcinoma: A TRANSLATIONAL STUDY.
Authors: Juan Sanabria , Udoh U1-3, Banerjee M2, Rajan PK1-3, Sanabria JD1-3, Sodhi K1-3, Pierre S2-3, Xie Z2-3, Shapiro J2-3, and Sanabria J1-4
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THE TUMOR SUPPRESOR ROLE OF THE A1-NA/K-ATPASE/SRC-P/PI3K SIGNALOSOME IN NASH RELATED HEPATOCELLULAR CARCINOMA: A TRANSLATIONAL STUDY.

Juan Sanabria
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Subspeciality
Reg: 8/24/2021 10:18:00 PM
Comment# 1
Hepatocellular Carcinoma (HCC) is the second and fastest-growing cause of cancer- related mortality worldwide, with an estimate of 0.84million cases every year. In the Western countries, due to the epidemic of obesity, non-alcoholic steatohepatitis (NASH) has become the major cause of HCC. Intriguingly, the molecular mechanisms that underpin the tumorigenesis of HCC from NASH are largely unknown. Here we show that in NASH-related malignancy, caveolar Src- phosphorylation at the &945;1-Na/K-ATPase (NKA) causes upregulation of the anti-apoptotic protein survivin and downregulation of the proapoptotic protein Smac/DIABLO, via the activation of the PI3K &8594; Akt pro-survival pathway with concomitant inhibition of the FoxO cascade, favoring cell division and primary liver carcinogenesis. Blocking this pathway using an inhibitory peptide, pNaKtide (developed from the &945;1-NKA subunit) resets the apoptotic switch from off-to-on in malignant cells, attenuating cancer progression and reducing liver fi

Comment added on 8/24/2021 10:18:00 PM 
     
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Most viewed poster for this congress
Poster: 1
Visits: 215
Title: Temporal and Spatial Dynamics of Hepatic Stellate Cell Activation in Intrahepatic Cholangiocarcinoma
Authors: Liqin Zhu , Cheng Tian, Liyuan Li, Qingfei Pan, Yizhen Li, Wentao Yang, Li Fan, Anthony Brown, Michelle Morrison, Kaushik K. Dey, Eric J. Norris, Jun J. Yang, Jiyang Yu, Evan S. Glazer
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Title: Autoimmunity and cancer immunosurveillance in the biliary tree
Authors: Jonathan Pol , J Paillet, S Lévesque, J Le Naour, C Plantureux, G Stoll, A Sauvat, P Caudana, J Tosello Boari, N Bloy, I Martins, P Opolon, A Delaune, N Robil, P de la Grange, J Hamroune, F Letourneur, PSC Leung, ME Gershwin, JS Zhu, MJ Kurth, B Lekbaby, J Augustin, Y Kim, S Gujar, C Coulouarn, L Fouassier, L Zitvogel, E Piaggio, C Housset, P Soussan, MC Maiuri, G Kroemer
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