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WFH 2016 World Congress

 

24-28 July 2016 Orlando
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Discussion forum - WFH 2016 World Congress
    Topic - Clotting Factor Concentrates

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Poster: 14
Visits: 27
Title: The effects of a long-acting factor IX product (N9-GP) on wound healing
Authors: Maureane Hoffman , Elizabeth P. Chappell PhD, Mirella Ezban PhD, Maureane Hoffman MD, PhD and Dougald M. Monroe
Centre: University of North Carolina

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THE EFFECTS OF A LONG-ACTING FACTOR IX PRODUCT (N9-GP) ON WOUND HEALING

Maureane Hoffman
Thread initiator
Subspeciality
Reg: 7/4/2016 8:43:00 PM

Comment# 1

. The purpose of the present study was to use a cutaneous wound healing model to evaluate the ability of a single dose of N9-GP to provide long-term hemostasis and support wound healing in HB mice . We and others have proposed that extra-vascular FIX plays an important role in hemostasis and wound healing. We hypothesized that since N9-GP does not enter the extravascular space in significant amounts, it might not improve wound healing in HB mice. However, a single injection of N9GP did normalize the time to wound closure, even though it did not completely normalize the tissue histology.

Comment added on 7/4/2016 8:43:00 PM 
     
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