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Discussion forum - 49th ERA-EDTA Congress
    Topic - Paediatric nephrology

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Poster: 721
Visits: 603
Title: Successful liver-kidney transplantation in a patient with ESRD due to homozygous factor H mutation
Authors: Tim Ulinski , Virginie Fouquet, Christine Grapin, Dominique Debray, Bilal Aoun, Véronique Frémeaux-Bacchi, Albert Bensman
Centre: Department of Paediatric Nephrology, Hpital Trousseau

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SUCCESSFUL LIVER-KIDNEY TRANSPLANTATION IN A PATIENT WITH ESRD DUE TO HOMOZYGOUS FACTOR H MUTATION

Tim Ulinski
Thread initiator
Subspeciality
Reg: 5/6/2012 12:08:00 PM

Comment# 1

End-stage renal disease (ESRD) in patients with aHUS due to factor H mutations are a challenge because there is very high risk of disease relapse in an isolated kidney graft, requiring preventive high dose plasma therapy or eculizimab treatment. Successful liver-kidney transplantations have been performed in several patients with heterozygout factor H mutations. We report the first patient with a homozygote factor H mutation and successful liver-kidney transplantation.Immunosuppressive regimen was basiliximab induction, oral prednisone, tacrolimus and mycophenolate mofetil. Three months post transplant serum creatinine was 75 mmol/l, proteinuria is negative and immunosuppression is well tolerated. All hepatic markers are normal.

Comment added on 5/6/2012 12:24:00 PM 
     
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